Apr 4, 2020 · Disruption of any one of these fat cell functions may lead to the development of systemic metabolic dysfunction. Adipose tissue has historically been classified into two types, …

This review focuses on the discussion of mechanisms causing or maintaining impaired adipose tissue function in obesity and potentially linking obesity to its associated disorders. A model is …

Independently of body mass index (BMI), adipose tissue dysfunction, increased visceral and ectopic fat accumulation, and inflammation may contribute to unhealthy obesity and …

The cellular composition, secretome, and location of these adipose depots define their function in health and metabolic disease. In obesity, adipose tissue becomes dysfunctional, promoting a …

Mar 1, 2021 · Adipose tissue inflammation is initiated and sustained over time by dysfunctional adipocytes that secrete inflammatory adipokines and by infiltration of bone marrow-derived …

Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue …

May 13, 2019 · In metabolically unhealthy obesity, the storage capacity of SAT, the largest WAT depot, is limited, and further caloric overload leads to the fat accumulation in ectopic tissues …

Aug 17, 2022 · Pincu et al. summarize the current knowledge on histopathological characteristics of AT dysfunction and propose the term obesity-related adipose tissue disease (OrAD) to …

Adipose tissue (AT) has pleiotropic functions under physiological conditions. It serves as protection for organs and body parts, exerts effects on reproduction, and is most importantly …

Adipose tissue inflammation is initiated and sustained over time by dysfunctional adipocytes that secrete inflammatory adipokines and by infiltration of bone marrow-derived immune cells that …