A U.S. military service member and three contractors have died following a plane crash in the Philippines, officials say.

At least two people were killed Friday after a small airplane crashed onto a busy road and collided with a bus in São Paulo, southern Brazil, injuring several others. Fire emergency services have rescued five people, Military Police Lieutenant Jefferson de Souza told CNN affiliate CNN Brasil.

The aircraft came down on the busy Marques de Sao Vicente Avenue, colliding with a bus on the ground. A passenger on the bus and a motorcyclist hit by debris were taken to hospital, while those who died were aboard the plane, fire department spokesperson Captain Maycon Cristo said.