Madness odds for Houston Cougars vs Duke Blue Devils Final Four NCAA Tournament game, including point spread, moneyline, over/under for betting.

The ACC was down bad this year and that's where Duke accumulated many of its numbers. Sure, the Blue Devils had non-conference wins, including against Auburn and Arizona, but wasn’t the Big 12 a lot better than the ACC this year? And Houston ripped through it, barring an OT loss to Texas Tech, which really should be playing this weekend.

After two exciting weekends of NCAA Tournament action, the 2025 Final Four field is set. The bracket started with 68 teams earlier this month, and the field has since shrunk to a mere quartet ahead of what should be a historic Final Four next weekend.

What you need to know about the Houston Cougars' Final Four semifinal against Duke, a rematch of last year's Sweet 16.

Cooper Flagg's point total is sky-high for this battle of No. 1 seeds when you consider what the Houston Cougars defense can do to the Duke Blue Devils attack, per Jason Logan's Final Four picks.

The Duke Blue Devils face the Houston Cougars in the Final Four of the men’s NCAA Tournament at the Alamodome in San Antonio, Texas, on Saturday, April 5, 2025.

Max Meyer spoke to sportsbooks about the betting action on the men's Final Four with biggest bets and line movement.

Who will take the final two steps in 2025 NCAA Tournament bracket? Our best Final Four March Madness predictions are in and they're right here

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.