The EMBO Journal20h
Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation
The bioenergetic requirements of muscle stem cells (satellite cells) during homeostasis and regeneration remain ill-defined. Here, genetics combined with multi-omics analyses reveal an essential role ...
eLife15d
Motor unit mechanisms of speed control in mouse locomotion
This valuable study characterises the activity of motor units from two of the three anatomical subdivisions ("heads") of the triceps muscle while mice walked on a treadmill at various speeds. Although ...
Frontiers16d
Deciphering the role of IGFBP5 in delaying fibrosis and sarcopenia in aging skeletal muscle: therapeutic implications and molecular mechanisms
Further research is needed to validate these findings and explore related clinical applications. Mouse skeletal muscle fibroblast cells (NOR-10) were purchased from the Shanghai Zhong Qiao Xin Zhou ...
EurekAlert!1mon
Gene therapy may be “one shot stop” for rare bone disease
In adult female mice with late-onset HPP, the greatest amount of activity occurred in the limb muscle, the site of ... but we’re only able to fix the skeletal mineralization.
Frontiers9mon
An intronic SNP affects skeletal muscle development by regulating the expression of TP63
Background: Porcine skeletal muscle development is pivotal for improving meat production. TP63, a transcription factor, regulates vital cellular processes, yet its role in skeletal muscle ...
eLife2y
Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function
Overall, this is an important study that demonstrates the power of proteomics-based systems genetics studies in the mouse. Building and maintaining healthy skeletal muscles is crucial for all stages ...