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Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.

The prince had PolG disease, a genetic mitochondrial disorder that prevents the body's cells from producing adequate energy.

Frederik de Nassau died on March 1, in Paris, a day after internationally recognized Rare Disease Day, which takes place on the last day of February.

Prince Frederik, the son of Europe's Prince Robert of Luxembourg, has died from a rare genetic disease, his family announced.