Background:In obesity and type 2 diabetes mellitus (T2D), adipose tissue expansion (because of larger adipocytes) results in reduced microvascular density which is thought to lead to adipocyte hypoxia ...

In the lean, healthy state, adipose tissue (AT) has critical roles in maintaining organismal homeostasis. Paramount among the various roles of AT is the regulation of whole body metabolism. While ...

In medically indicated weight loss, attention is typically focused on the associated health benefits. However, recent ...

Growing evidence suggests a critical role for overnutrition in the development of low-grade inflammation. Specifically, chronic inflammation in adipose tissue is considered a crucial risk factor for ...

Guo and his group at MIT set out to look into the mechanics of tissue deformation, and the role of intercellular flow in particular, following a study they published in 2020.

Nucleus pulposus (NP) tissue engineering has been demonstrated to be a feasible therapeutic strategy for intervertebral disc regeneration. In this study, we constructed a novel injectable biomaterial ...

New nanobody-based method, POD-nAb/FT-GO 3D-IHC, enables ultra-fast, high-resolution labeling of neurons and glia deep within 1-mm-thick brain tissue, revealing cellular structures in just three days.

With the aid of a 3D printer, researchers at Uppsala University have succeeded in creating a model that resembles human nerve tissue. The model, which can be cultured from the patient’s own ...

Endocannabinoids modulate insulin and adipokine expression in adipocytes through cannabinoid receptors and their levels are elevated during hyperglycemia and obesity, but little is known about how ...

For the first time in nearly 30 years, scientists have discovered the heaviest atomic nucleus ever observed that decays by emitting a proton—a rare and fascinating process in nuclear physics.

Nucleus Genomics has been courting controversy for years with products that claim to tell people how their genetics correlate to a host of complex issues, including their IQ.