The San Francisco 49ers may have to alter course on their plan to play starters in the preseason vs. the Las Vegas Raiders.

The San Francisco 49ers' brutal injury luck continues, as they've now lost offensive tackle Andre Dillard for the year.

So far, so good for the San Francisco 49ers and running back Christian McCaffrey after his injury issues in 2024.

The San Francisco 49ers placed Bradlee Anae on injured reserve on Wednesday, and after successful workouts, they're bringing in two EDGE defenders.

The San Francisco 49ers couldn't get through their joint practice with the Las Vegas Raiders without an injury scare.

The San Francisco 49ers are bringing back an old friend, as they've signed Malik Turner for a third time in four years.

San Francisco 49ers third-round pick Nick Martin wasn't great against the Denver Broncos, but defensive coordinator Robert ...

The San Francisco 49ers are looking for someone to step up at safety, and their fifth-round pick may be separating himself ...

The San Francisco 49ers rookies had up-and-down performances against the Denver Broncos in Week 1 of the NFL preseason.

The 49ers finally shared a potential return timeline for wide receiver Brandon Aiyuk from his knee injury, too. Though it ...

The San Francisco 49ers preseason slate opened Saturday evening with a 30-9 loss to the Denver Broncos at Levi's Stadium.

The San Francisco 49ers lost a defensive end and picked up a wide receiver in their roster moves before joint practice with the Raiders.