Final Four picks, predictions, odds for Duke Blue Devils vs Houston Cougars NCAA Tournament March Madness game Saturday, April 5, 2025. Who wins game?

It’s the Duke Blue Devils vs Houston in the Final Four of the March Madness bracket. Here’s our prediction, pick for the 2025 NCAA Tournament game.

The Duke Blue Devils face the Houston Cougars in the Final Four of the men’s NCAA Tournament at the Alamodome in San Antonio, Texas, on Saturday, April 5, 2025.

Auburn and Florida will get the Final Four started on Saturday at 6:09 ET. The Duke-Houston matchup will be roughly 30 minutes after the conclusion of game one. Both games will take place at the Alamodome in San Antonio, Texas, and they will both be airing on CBS.

Purdue's Braden Smith has been announced as a Naismith All-American. Smith joins the prestigious list of 10 Naismith All-Americans, featuring a couple of college basketball's biggest stars, such as Duke's Cooper Flagg, Auburn's John Broome, Houston's L.J. Cryer and Alabama's Mark Sears.

Final Four picks, predictions, odds explain why Houston Cougars will beat Duke Blue Devils in NCAA Tournament March Madness game Saturday, April 5.

NCAA Tournament Final Four matchup between the Duke Blue Devils and Houston Cougars with predictions, odds, picks, spread, betting lines and more.

Houston basketball is prepared for the challenge in its Final Four matchup against Duke, and it's going to be a classic showdown.